Tuning particle biodegradation through polymer-peptide blend composition

ST Gunawan; K Kempe; GK Such; J Cui; K Liang; JJ Richardson; APR Johnston; F Caruso

Journal article

Tuning particle biodegradation through polymer-peptide blend composition

ST Gunawan, K Kempe, GK Such, J Cui, K Liang, JJ Richardson, APR Johnston, F Caruso

Biomacromolecules | Published : 2014

DOI: 10.1021/bm5012272

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Abstract

We report the preparation of polymer-peptide blend replica particles via the mesoporous silica (MS) templated assembly of poly(ethylene glycol)-block-poly(2-diisopropylaminoethyl methacrylate-co-2-(2-(2-(prop-2-ynyloxy)ethoxy)ethoxy)ethyl methacrylate) (PEG45-b-P(DPA55-co-PgTEGMA4)) and poly(l-histidine) (PHis). PEG45-b-P(DPA55-co-PgTEGMA4) was synthesized by atom transfer radical polymerization (ATRP), and was coinfiltrated with PHis into poly(methacrylic acid) (PMA)-coated MS particles assembled from different peptide-to-polymer ratios (1:1, 1:5, 1:10, or 1:15). Subsequent removal of the sacrificial templates and PMA resulted in monodisperse, colloidally stable, noncovalently cross-linked ..

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University of Melbourne Researchers

Georgina Such Author

Frank Caruso Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This research was funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (CE140100036) and by the Australian Research Council under the Australian Laureate Fellowship (F.C, FL120100030), Super Science Fellowship (F.C., FS110200025), and Australian Future Fellowship (G.K.S, FT120100564, and A.P.R.J., FT110100265) schemes. K.K. is grateful to the Alexander von Humboldt-Foundation for a Feodor-Lynen Fellowship.